News

New York City-based Ember Therapeutics, a biopharmaceutical company, has agreed to sell its OP-1 product family and related assets, to Viscogliosi Brothers LLC, a private equity firm focused on developing neuromusculoskeletal technologies. No financial terms were disclosed.

PRESS RELEASE

NEW YORK, Aug. 16, 2018 /PRNewswire/ — Ember Therapeutics, Inc., a clinical stage biopharmaceutical company focused on the clinical application of Bone Morphogenetic Protein-7 (BMP-7), announced today that it has entered into a letter of intent with Viscogliosi Brothers, LLC (VB), a private equity investment firm focused on developing innovative neuromusculoskeletal technologies, for the sale of its OP-1 product family and related assets, which includes OP-1 Implant, OP-1 Putty, Opgenra and Osigraft for use in orthopaedic bone applications.

Ember Therapeutics had acquired the exclusive, worldwide license to the BMP-7 and OP-1 portfolio and associated intellectual property from Stryker Corporation in 2014. The previously commercialized OP-1 product portfolio had at one point generated approximately $100M in annual revenues for Stryker and had been viewed as a formidable competitor to Medtronic’s Infuse.

The transaction is expected to close in late Q3 or Q4 of this year and is subject to financing. “This transaction allows Ember to continue to focus on our exciting late stage osteoarthritis (OA) program which offers the potential of addressing the actual cause of this debilitating disease by regrowing cartilage in the knee. OP-1, a related product for bone, has an immense amount of potential as has been previously used in over 50,000 patients,” stated Joseph Hernandez, Executive Chairman of Ember Therapeutics. “We are excited to be working with the Viscogliosi Brothers in their efforts to commercially relaunch these products.”

“We believe bone repair and regeneration is the future of orthopaedic healthcare,” stated Anthony G. Viscogliosi, principal of Viscogliosi Brothers, LLC. “VB is delighted to have access once again to the previously commercialized OP-1 product family formerly owned by Stryker Biotech. This is the second publicly announced step VB has taken in the direction of assembling what we believe will be the leading global portfolio of BMP technology for stimulating bone growth.”

About Ember Therapeutics, Inc.
Ember Therapeutics, Inc. is a pharmaceutical company developing targeted therapies for pain, osteoarthritis, kidney fibrosis and other regenerative medicines. In particular, Ember Therapeutics, Inc. has two commercial stage products and a late stage Phase 3 ready assets. For more information, please visit www.embertx.com.

About Viscogliosi Brothers, LLC
Established by Marc R. Viscogliosi, John J. Viscogliosi and Anthony G. Viscogliosi in New York City, in 1999, Viscogliosi Brothers, LLC (VB), is a family office holding company specializing in venture capital, private equity and merchant banking in the neuro-musculoskeletal/orthopedic industry.

VB’s vision is dedicated to improving healthcare and the quality of life for humanity by finding innovative orthopedic concepts and supporting them to become sustainable technologies that can be commercialized globally to lead the evolution in orthopedic standards of care.

To accomplish this vision, VB discovers technologies, creates products and develops, builds, operates and finances companies founded on innovative and “life changing” technologies. VB principals have participated in more than 300 transactions, have invested in more than 20 companies and have formed more than ten funds.

Companies and funds that VB participated in have generated more than $1.5 billion in exit proceeds for investors through 14 exits in the last 18 years. Through its portfolio companies VB has defined 7 new orthopedic industry categories and its investments have helped commercialize more than 75 medtech devices, including eleven number one orthopedic technologies in seven market leading businesses.

VB orthopedic portfolio companies’ products have been implanted in nearly 300,000 people in more than 70 countries globally.

For more information, please visit www.vbllc.com.